Semaglutide, conversely, has stronger clinical backing
It depends on your goals and current B12 levels
Based on self-reported data from approximately 300,000 Remedy Meds members on a personalized treatment plan, including compounded GLP-1 medications and consultations with medical professionals, compared to outcomes reported for GLP-1 medications alone in Rodriguez P., et al
Tirzepatide engages GIP near the strength of the natural hormone but activates GLP-1 about 18 times more weakly than natural GLP-1. After accounting for protein binding in blood, the drug is roughly 20-fold GIP-forward and has no meaningful glucagon activity
While B12 is found in foods like meat, eggs, and dairy, many peopleespecially vegetarians, vegans, and those with absorption issuesmay struggle to maintain optimal levels